Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity

作者：Ignat Adriana^*; Gaina Luiza; Kuete Victor; Silaghi Dumitrescu Luminita; Efferth Thomas; Zaharia Valentin

来源：Molecules, 2013, 18(4): 4679-4688.

DOI：10.3390/molecules18044679

• selenazole
• microwave assisted synthesis
• cytotoxicity

New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with alpha-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, H-1-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).

• 出版日期2013-4