ASYMMETRIC HYDROGENATION OF AROMATIC HETEROCYCLIC KETONES CATALYZED BY THE MsDPEN-Cp*Ir(III) COMPLEX

作者：Utsumi Noriyuki^*; Tsutsumi Kunihiko; Watanabe Masahiko; Murata Kunihiko; Arai Noriyoshi; Kurono Nobuhito; Ohkume Takeshi

来源：Heterocycles, 2010, 80(1): 141-147.

DOI：10.3987/COM-09-S(S)34

• Asymmetric Hydrogenation
• Chiral Alchohol
• Enantioselective Reaction
• Iridium Catalyst
• Ketone

Asymmetric hydrogenation of aromatic heterocyclic ketones catalyzed by Cp*Ir(OTf)(Msdpen) (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) affords the heterocyclic alcohols in 93% to >99% ee. The reaction is conducted in a methanolic solution with a substrate-to-catalyst molar ratio of 200-5000 under 15 atm of H-2. The heterocyclic rings of substrates are left intact.

• 出版日期2010-1-1