NRF-1 genotypes and endurance exercise capacity in young Chinese men

作者：He Z; Hu Y^*; Feng L; Li Y; Liu G; Xi Y; Wen L; Lucia A

来源：British Journal of Sports Medicine, 2008, 42(5): 361.

DOI：10.1136/bjsm.2007.042945

Background: Nuclear respiratory factor 1 (NRF-1) is a critical component of the energy-sensing mechanism in mammalian cells, and translates physiological signals ( particularly those induced by exercise) into increased capacity for mitochondrial biogenesis and oxidative phosphorylation.
Objective: To study the possible association between rs2402970, rs6949152 and rs10500120 NRF-1 genotypes and several phenotypes indicative of maximum (VO(2max)) and submaximum aerobic capacity (ventilatory threshold (VT) and metabolic cost of submaximum running at 12 km/hour ( running economy; RE)) both at baseline and in response to a 18-week endurance training programme in young Chinese men of Han origin (n=102; 19 (SD 1) years).
Results: For rs2402970, a significant genotype effect was seen for VT (p=0.004) and RE (p=0.027). For rs6949152, a significant interaction (genotype x training) effect (p=0.047) was found for VT.
Conclusions: There is an association between NRF-1 genotypes ( rs2402970 and rs6949152 polymorphisms) and the baseline and/or training response of human aerobic capacity. More research is needed to corroborate our data in other ethnic groups with lower fitness levels at the pre-training state ( particularly Caucasians) and to identify the molecular mechanisms involved in the genotype-phenotype associations we found.

• 出版日期2008-5
• 单位北京体育大学; 天津体育学院; 国家体育总局体育科学研究所