AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration

作者：Shih Wen Ling^*; Liao Ming Hue; Yu Feng Ling; Lin Ping Yuan; Hsu Hsue Yin; Chiu Shu Jun

来源：Cancer Letters, 2008, 270(2): 202-217.

DOI：10.1016/j.canlet.2008.05.005

• AMF/PGI
• MMP-3
• Src
• RhoA
• Phosphatidylinositol 3-kinase

We have previously shown that AMF/PGI induces hepatoma cell migration through the induction of MMP-3. This work investigates how AMF/PGI activates the MMP-3 gene. We demonstrated that AMF/PGI transactivates the MMP-3 gene promoter through AP-1. The transactivation and induction of cell migration effect of AMF/PGI directly correlates with its enzymatic activity. Various analyses showed that AMF/PGI stimulated the Src-RhoA-PI3-kinase signaling pathway, and these three signaling molecules could form a complex. Our results demonstrate a new mechanism of AMF/PGI-induced cell migration and a link between Src-RhoA-PI3-kinase, AP-1, MMP-3 and hepatoma cell migration.

• 出版日期2008-11-8