Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework

作者：Offringa Rienk^*; Glennie Martin J

来源：Cancer Cell, 2015, 28(3): 273-275.

DOI：10.1016/j.ccell.2015.08.008

In this issue of Cancer Cell, Dahan and colleagues demonstrate that the Fe region has a significant impact on the therapeutic capacity of checkpoint inhibitor antibodies targeting the PD-1/PD-L1 axis in pre-clinical tumor models. This work provides important insights with respect to the further clinical development of checkpoint inhibitors.

• 出版日期2015-9-14