New insights into the pathophysiology of nonalcoholic fatty liver disease

作者：Chavez Tapia Norberto C; Uribe Misael; Ponciano Rodriguez Guadalupe; Medina Santillan Roberto; Mendez Sanchez Nahum^*

来源：Annals of Hepatology, 2009, 8: S9-S17.

DOI：10.1016/s1665-2681(19)31821-6

• Fatty acids
• immune response
• vagus nerve
• steatosis
• insulin resistance

The consequences of pathologic adipose tissue accumulation have been described for almost all organs. Nonalcoholic fatty liver disease (NAFLD) is considered the most relevant hepatic manifestation of obesity. There is great interest in the study of NAFLD, and new insights into its pathogenic process have been described. Currently, in addition to insulin resistance, which was considered the hallmark of this disease, endocrine, immunologic, and central nervous system factors are attracting interest as explanatory variables. In this review, new factors associated with the main theories on the pathophysiology of NAFLD are analyzed.

• 出版日期2009