A re-investigation of [Fe(L-cysteinate)(2)(CO)(2)](2-): an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

作者：Hewison Lindsay; Johnson Tony R; Mann Brian E^*; Meijer Anthony J H M; Sawle Philip; Motterlini Roberto

来源：Dalton Transactions, 2011, 40(33): 8328-8334.

DOI：10.1039/c1dt10338e

[Fe(L-cysteinate)(2)(CO)(2)](2-) is a CO releasing molecule which has low cytotoxicity to RAW264.7 macrophages. It provides an example of CO binding using ligands available to ion channels which use CO as a signalling molecule in the absence of heme. Previous work has shown that this compound consists of five isomers and it was proposed that the two isomers with trans-dicarbonyls are dominant. In this work the isomers are re-assigned and shown to be capable of releasing CO, albeit too slowly to act as a signalling receptor. It is shown that by linking the two L-cysteines together to form [Fe(SCH2CH{CO2H}NHCH2)(2)(CO)(2)], only one isomer is isolated.

• 出版日期2011
• 单位河北医科大学