Apply peptide C-terminal semicarbazides to peptide segment coupling using transfer active ester condensation technology

作者：Wang Pu^*

来源：Tetrahedron Letters, 2007, 48(41): 7313-7315.

DOI：10.1016/j.tetlet.2007.08.035

• peptide C-terminal semicarbazide
• HOCt active esters
• segment coupling

Peptide C-terminal semicarbazides are used as the starting materials in transfer active ester condensation technology to prepare HOCt active esters intermediates, which react with other peptide segments or reagents to afford long chain peptides, branch peptides and peptide C-terminal derivatives. The semicarbazido derivatives afford reliable results and avoid side reactions efficiently.

• 出版日期2007-10-8
• 单位山东大学; 河北医科大学