Applications of ambient mass spectrometry in high-throughput screening

作者：Li, Li-Ping; Feng, Bao-Sheng; Yang, Jian-Wang; Chang, Cui-Lan; Bai, Yu^*; Liu, Hu-Wei

来源：Analyst, 2013, 138(11): 3097-3103.

DOI：10.1039/c3an00119a

• DESORPTION ELECTROSPRAY-IONIZATION
• TIME-OF-FLIGHT
• PRESSURE CHEMICAL-IONIZATION
• PHTHALIC-ACID ESTERS
• POLY(VINYL CHLORIDE)
• QUANTITATIVE-ANALYSIS
• RAPID IDENTIFICATION
• ILLICIT DRUGS
• ION-SOURCE
• EESI-MS

The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).

• 出版日期2013
• 单位北京大学