科研之友
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摘要
Background: Chronic rhinosinusitis (CRS) has a multifactorial etiology, with a debate about the role of inhalant allergy in the pathogenesis of CRS. Objective: This study assessed the impact of allergy status on externalized paranasal sinuses after tumor resection to determine if a predisposition to inhalant allergy brought about additional inflammation after sinus surgery. Methodology: A case-control study was performed on patients who had no history of CRS who underwent paranasal sinus tumor resection. Allergic sensitization was defined by a positive serum ImmunoCAP test result. Outcomes were measured at least 6 months after surgery by using the modified Lund-MacKay endoscopic score and the 22-item Sino-Nasal Outcome test, with rhinitis, sleep, psychological, ear and/or facial, and sinus subscores to assess the impact of allergy status on mucosal inflammation. Results: A total of 103 patients (53.44 +/- 17.46 years; 46% women) were assessed. Of these, 61.17% were allergically sensitized at the time of surgery. Postsurgery endoscopic assessment was similar [the modified Lund-Mackay endoscopic score allergic sensitized 0.5 (1.7) versus nonallergic sensitized 0.0 (0.9); p = 0.15]. Sinonasal symptoms were also similar between the groups' 22- item Sino-Nasal Outcome test scores, allergic sensitized versus allergic nonsensitized, (allergic 28.9 +/- 20.8 versus nonallergic 33.5 +/- 19.7; p = 0.31), rhinitis score (5.9 +/- 5.5 versus 6.4 +/- 4.7; p = 0.66), sleep score (6.9 +/- 5.9 versus 7.7 +/- 4.8; p = 0.50), ear and/or facial symptom score (3.4 +/- 3.6 versus 4.3 +/- 3.3; p = 0.22), psychological score (6.9 +/- 6.0 versus 8.3 +/- 6.7; p = 0.29), and of nasal symptom score (6.4 +/- 5.2 versus 7.0 +/- 5.3; p = 0.61). Conclusions: Externalization of the sinuses in patients with inhalant allergy did not bring about significant additional inflammation in patients after tumor surgery.
- 出版日期2017-2
