An Insight into the Sialotranscriptome of Triatoma matogrossensis, a Kissing Bug Associated with Fogo Selvagem in South America

作者：Assumpcao Teresa C F; Eaton Donald P; Pham Van M; Francischetti Ivo M B; Aoki Valeria; Hans Filho Gunter; Rivitti Evandro A; Valenzuela Jesus G; Diaz Luis A; Ribeiro Jose M C^*

来源：The American Journal of Tropical Medicine and Hygiene, 2012, 86(6): 1005-1014.

DOI：10.4269/ajtmh.2012.11-0690

Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature.

• 出版日期2012-6