A Strategy for Direct Mapping and Identification of Mutations by Whole-Genome Sequencing

作者:Zuryn Steven; Le Gras Stephanie; Jamet Karine; Jarriault Sophie*
来源:Genetics, 2010, 186(1): 427-430.
DOI:10.1534/genetics.110.119230

摘要

Mutant screens have proven powerful for genetic dissection of a myriad of biological processes, but subsequent identification and isolation of the causative mutations are usually complex and time consuming. We have made the process easier by establishing a novel strategy that employs whole-genome sequencing to simultaneously map and identify mutations without the need for any prior genetic mapping.

  • 出版日期2010-9