Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

作者：Jordan Iolanda^*; Corniero Patricia; Balaguer Monica; Ortiz Jessica; Vila David; Velasco Jesus; Cambra Francisco J; Esteban Elisabeth

来源：Biomarkers in Medicine, 2014, 8(9): 1065-1072.

DOI：10.2217/BMM.14.77

• adrenomedullin
• C-reactive protein
• diagnostic
• procalcitonin
• sepsis

Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 +/- 4.3 vs 1.6 +/- 2.4) and inotropes (4.4 +/- 5.2 vs 1.3 +/- 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

• 出版日期2014