A Deep Belief Network and Dempster-Shafer-Based Multiclassifier for the Pathology Stage of Prostate Cancer

作者：Kim Jae Kwon; Choi Mun Joo; Lee Jong Sik; Hong Jun Hyuk; Kim Choung Soo; Seo Seong Il; Jeong Chang Wook; Byun Seok Soo; Koo Kyo Chul; Chung Byung Ha; Park Yong Hyun; Lee Ji Youl; Choi In Young

来源：Journal of Healthcare Engineering, 2018, 2018: 4651582.

DOI：10.1155/2018/4651582

<jats:p><jats:italic>Object</jats:italic>. Pathologic prediction of prostate cancer can be made by predicting the patient’s prostate metastasis prior to surgery based on biopsy information. Because biopsy variables associated with pathology have uncertainty regarding individual patient differences, a method for classification according to these variables is needed. <jats:italic>Method</jats:italic>. We propose a deep belief network and Dempster-Shafer- (DBN-DS-) based multiclassifier for the pathologic prediction of prostate cancer. The DBN-DS learns prostate-specific antigen (PSA), Gleason score, and clinical T stage variable information using three DBNs. Uncertainty regarding the predicted output was removed from the DBN and combined with information from DS to make a correct decision. <jats:italic>Result</jats:italic>. The new method was validated on pathology data from 6342 patients with prostate cancer. The pathology stages consisted of organ-confined disease (OCD; 3892 patients) and non-organ-confined disease (NOCD; 2453 patients). The results showed that the accuracy of the proposed DBN-DS was 81.27%, which is higher than the 64.14% of the Partin table. <jats:italic>Conclusion</jats:italic>. The proposed DBN-DS is more effective than other methods in predicting pathology stage. The performance is high because of the linear combination using the results of pathology-related features. The proposed method may be effective in decision support for prostate cancer treatment.</jats:p>

• 出版日期2018