Anchoring Ligand-Effect on Bright Contrast-Enhancing Property of Hollow Mn3O4 Nanoparticle in T-1-Weighted Magnetic Resonance Imaging

作者：Lee Jihwan; Kumari Nitee; Kim Soo Min; Kim Seonock; Jeon Ki Wan; Im Geun Ho; Jang Moon Sun; Lee Won Jae; Lee Jung Hee^*; Lee In Su^*

来源：Chemistry of Materials, 2018, 30(12): 4056-4064.

DOI：10.1021/acs.chemmater.8b00854

Here, we describe and conceptualize the influence of surface engineering for hollow manganese oxide nanoparticles (HMONs)-based contrast agents for magnetic resonance imaging (MRI). A systematic study has been conducted for enhancing the relaxivities of HMONs by functionalizing their surface with various capping ligands having different anchoring groups (carboxylate, alcohol, thiol, and amine). Among all studied ligands, carboxylate-anchored ligands exhibit significant increase in magnetization value upon surface capping of HMON. Contrary to the previous hypotheses based on the surface-Mn2+ ions accessibility to water molecules, we proposed surface capping induced magnetization in HMON is responsible for the enhanced relaxivity (r(1)) value. Further, in vivo imaging efficacy of oleate-capped HMON (OA-HMON) has been demonstrated in mouse brain. This study provides an insightful understanding of contrast enhancement and modulation by surface ligands on manganese oxide-based T-1-contrast agents.

• 出版日期2018-6-26