Neural Control of Ventricular Rate in Ambulatory Dogs With Pacing-Induced Sustained Atrial Fibrillation

作者：Park Hyung Wook; Shen Mark J; Han Seongwook; Shinohara Tetsuji; Maruyama Mitsunori; Lee Young Soo; Shen Changyu; Hwang Chun; Chen Lan S; Fishbein Michael C; Lin Shien Fong; Chen Peng Sheng^*

来源：Circulation-Arrhythmia and Electrophysiology, 2012, 5(3): 571-580.

DOI：10.1161/CIRCEP.111.967737

• atrial fibrillation
• atrioventricular node
• autonomic nervous system
• ECG
• ventricular rate

Background-We hypothesize that inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) is responsible for ventricular rate (VR) control during atrial fibrillation (AF) in ambulatory dogs. %26lt;br%26gt;Methods and Results-We recorded bilateral cervical vagal nerve activity (VNA) and IVC-IAGPNA during baseline sinus rhythm and during pacing-induced sustained AF in 6 ambulatory dogs. Integrated nerve activities and average VR were measured every 10 seconds over 24 hours. Left VNA was associated with VR reduction during AF in 5 dogs (from 211 bpm [95% CI, 186-233] to 178 bpm [95% CI, 145-210]; P%26lt;0.001) and right VNA in 1 dog (from 208 bpm [95% CI, 197-223] to 181 bpm [95% CI, 163-200]; P%26lt;0.01). There were good correlations between IVC-IAGPNA and left VNA in the former 5 dogs and between IVC-IAGPNA and right VNA in the last dog. IVC-IAGPNA was associated with VR reduction in all dogs studied. Right VNA was associated with baseline sinus rate reduction from 105 bpm (95% CI, 95-116) to 77 bpm (95% CI, 64-91; P%26lt;0.01) in 4 dogs, whereas left VNA was associated with sinus rate reduction from 111 bpm (95% CI, 90-1250) to 81 bpm (95% CI, 67-103; P%26lt;0.01) in 2 dogs. %26lt;br%26gt;Conclusions-IVC-IAGPNA is invariably associated with VR reduction during AF. In comparison, right or left VNA was associated with VR reduction only when it coactivates with the IVC-IAGPNA. The vagal nerve that controls VR during AF may be different from that which controls sinus rhythm. (Circ Arrhythm Electrophysiol. 2012;5:571-580.)

• 出版日期2012-6