Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus

作者：Sui, Xiuwen; Yin, Jiechao; Ren, Xiaofeng^*

来源：Antiviral Research, 2010, 85(2): 346-353.

DOI：10.1016/j.antiviral.2009.10.014

• Diammonium glycyrrhizinate
• Lithium chloride
• Pseudorabies virus (PrV)
• Apoptosis

Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection.

• 出版日期2010-2
• 单位东北农业大学