Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation

作者：Kawasaki Ichiro; Jeong Myung Hwan; Oh Bong Kyeong; Shim Yhong Hee^*

来源：FEBS Letters, 2010, 584(16): 3587-3591.

DOI：10.1016/j.febslet.2010.07.026

• Apigenin
• Flavone
• DAF-16
• DAF-2
• Growth inhibition
• Caenorhabditis elegans

Treatment of Caenorhabditis elegans with apigenin, 5,7,4 '-trihydroxyflavone, induces larval growth inhibition. To understand the molecular basis of apigenin-induced larval growth inhibition, the effects of apigenin on DAF-16 activity were examined. DAF-16 was activated through nuclear translocation and the mRNA level of sod-3, one of the known DAF-16 target genes, was increased upon apigenin treatment. DAF-16 activity was required for the growth inhibition, since the larval growth retardation upon apigenin treatment was suppressed in daf-16 mutants. These results indicate that apigenin acts as a stressor that activates DAF-16, which in turn inhibits larval growth.

• 出版日期2010-8-20