Development of a prelabeling approach for a targeted nanochelator

作者：Fitzsimmons Jonathan^*; Atcher Robert; Cutler Cathy

来源：Journal of Radioanalytical and Nuclear Chemistry, 2015, 305(1): 161-167.

DOI：10.1007/s10967-015-3976-x

• Ac-225
• Pm-149
• Prelabeling
• PEI
• Radioimmunotherapy
• Polyethyleneimine

The polymer polyethyleneimine with primary and secondary chelators can retain Ac-225 and its daughters. In this study we optimize a prelabeling approach, followed by addition of secondary chelators and explore crosslinking approaches to add a targeting molecule. A (N-Succinimidyl 3-(2-pyridyldithio)-propionate crosslinking approach was used to obtain a similar to 1 to 1 ratio of the modified PEI to Trastuzumab. This approach coupled with the prelabeling approach would allow the synthesis of the radiolabeled targeted polymer for Ac-225 radioimmunotherapy.

• 出版日期2015-7
• 单位Los Alamos