Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

作者：Kabadi Shruti V; Faden Alan I^*

来源：International Journal of Molecular Sciences, 2014, 15(1): 1216-1236.

DOI：10.3390/ijms15011216

• clinical trial design
• multipotential neuroprotective approaches
• microglial and astrocyte activation
• programmed cell death
• experimental head injury
• translational challenges
• caspase-dependent and AIF-mediated cell death
• autophagy

Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, more than 30 clinical trials of neuroprotection in TBI patients have failed. In part, these failures likely reflect methodological differences between the clinical and animal studies, as well as inadequate pre-clinical evaluation and/or trial design problems. However, recent changes in experimental approach and advances in clinical trial methodology have raised the potential for successful clinical translation. Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI.

• 出版日期2014-1