Anti-Inflammatory Activity and Chemical Profile of Galphimia glauca

作者：Gonzalez Cortazar Manases; Herrera Ruiz Maribel^*; Zamilpa Alejandro; Jimenez Ferrer Enrique; Marquina Silvia; Alvarez Laura; Tortoriello Jaime

来源：Planta Medica, 2014, 80(1): 90-96.

DOI：10.1055/s-0033-1360150

• Galphimia glauca
• Malpighiaceae
• galphimine
• nor-secotriterpene
• anti-inflammatory activity
• flavonoid
• organic acids

Galphimia glauca, commonly known as flor de estrella, is a plant species used in Mexican traditional medicine for the treatment of different diseases that have an acute or chronic inflammatory process in common. Aerial parts of this plant contain nor-seco-triterpenoids with anxiolytic properties, which have been denominated galphimines. Other compounds identified in the plant are tetragalloyl-quinic acid, gallic acid, and quercetin, which are able to inhibit the bronchial obstruction induced by platelet-activating factor. The objective of this work was to evaluate the anti-inflammatory effect of crude extracts from G. glauca and, by means of bioguided chemical separation, to identify the compounds responsible for this pharmacological activity. n-Hexane, ethyl acetate, dichloromethane, and methanol extracts showed an important anti-inflammatory effect. Chemical separation of the active methanol extract allowed us to identify the nor-seco-triterpenes galphimine-A (1) and galphimine-E (3) as the anti-inflammatory principles. Analysis of structure-activity relationships evidenced that the presence of an oxygenated function in C6 is absolutely necessary to show activity. In this work, the isolation and structural elucidation of two new nor-seco-triterpenes denominated as galphimine-K (4) and galphimine-L (5), together with different alkanes, fatty acids, as well as three flavonoids (17-19), are described, to our knowledge for the first time, from Galphimia glauca.

• 出版日期2014-1