Aminoferrocene lithiation by boron trifluoride activation

作者：Metallinos Costa^*; Zaifman Josh; Dodge Laura

来源：Organic Letters, 2008, 10(16): 3527-3530.

DOI：10.1021/ol8013182

Lithiation of BF(3)-complexed dimethylaminoferrocene occurs exclusively ortho to the dimethylamino group in the cyclopentadienyl ring providing structurally diverse products in 76-94% yield after electrophile quench. This method represents the first direct C2-lithiation of a monosubstituted aminoferrocene, offering rapid and complementary access to this class of compounds over procedures that utilize carbon- and sulfur-based directing groups and may serve as a prelude to an asymmetric process.

• 出版日期2008-8-21