Multivariate tensor-based morphometry on surfaces: Application to mapping ventricular abnormalities in HIV/AIDS

作者：Wang Yalin^*; Zhang Jie; Gutman Boris; Chan Tony F; Becker James T; Aizenstein Howard J; Lopez Oscar L; Tamburo Robert J; Toga Arthur W; Thompson Paul M

来源：NeuroImage, 2010, 49(3): 2141-2157.

DOI：10.1016/j.neuroimage.2009.10.086

Here we developed a new method, called multivariate tensor-based surface morphometry (TBM), and applied it to study lateral ventricular Surface differences associated with HIV/AIDS Using concepts from differential geometry and the theory of differential for ins, we created mathematical structures known as holomorphic one-forms, to obtain an efficient and accurate conformal parameterization of the lateral ventricular surfaces in the brain. The new meshing approach also provides a natural way to register anatomical Surfaces across Subjects. and improves on prior methods as it handles surfaces that branch and join at complex 3D Junctions To analyze anatomical differences, we computed new statistics from the Riemannian surface metrics-these retain multivariate information oil local surface geometry We applied this framework to analyze lateral ventricular surface morphometry in 31) MRI data from 11 Subjects with HIV/AIDS and 8 healthy controls Our method detected a 3D profile of surface abnormalities even in this small sample. multivariate statistics on the local tensors gave better effect sizes for detecting group differences, relative to other TBM-based methods including analysis of the Jacobian determinant, the largest and smallest eigenvalues of the Surface metric, and the pair of eigenvalues of the Jacobian matrix The resulting analysis pipeline may improve the power of surface-based morphometry studies of the brain.

• 出版日期2010-2-1