A new and highly efficient water-soluble copper complex for the oxidation of secondary 1-heteroaryl alcohols by tert-butyl hydroperoxide

作者：Boudreau J; Doucette M; Ajjou AN^*

来源：Tetrahedron Letters, 2006, 47(11): 1695-1698.

DOI：10.1016/j.tetlet.2006.01.061

• oxidation
• water-soluble catalyst
• copper chloride
• tert-butyl hydroperoxide
• 1-heteroaryl alcohols
• heteroaromatic ketones

The water-soluble copper complex generated in situ from CuCl2 and 2,2 '-biquinoline-4,4 '-dicarboxylic acid dipotassium salt (BQC), has been revealed as a highly efficient and selective catalyst for the oxidation of secondary 1-heteroaryl alcohols to the corresponding heteroaromatic ketones With aqueous tert-butyl hydroperoxide, under mild conditions. The catalytic system is compatible with different heterocycles such as pyridines, pyrroles, indoles, thiophens, furans, thiazoles, and imidazoles.

• 出版日期2006-3-13