摘要
We have designed and synthesized colchicine-derived prodrug 7, which is composed of a 4-chlorocolchicine derivative, a dipeptide side chain cleavable by cathepsin B, a spacer containing a disulfide bond, and hydrophobic vitamin E. Prodrug 7 was capable of forming nanoparticles by self-assembly. Mean particle diameter evaluated by dynamic light scattering measurement was ca. 205 nm.
- 出版日期2017-1-25