Assessment of the Macula in Keratoconus: An Optical Coherence Tomography and Multifocal Electroretinography Study

作者：Moschos Marilita M^*; Chatziralli Irini P; Koutsandrea Chryssanthi; Siasou Georgia; Droutsas Dimitrios

来源：Ophthalmologica, 2013, 229(4): 203-207.

DOI：10.1159/000350801

• Keratoconus
• Macular thickness
• Optical coherence tomography
• Retinal response density

Purpose: The purpose of our study was to assess the macular thickness and the electrophysiological changes in keratoconic patients without any systemic or ocular disorders. Methods: 64 eyes of 32 keratoconus patients as well as 60 eyes of 30 controls participated in the study. All participants underwent a complete ophthalmological examination, including best-corrected visual acuity (BCVA) assessment, color vision testing, fundus examination, intraocular pressure measurement, central foveal thickness (CFT) measurement by optical coherence tomography (OCT) scan, and multifocal-electroretinogram (mf-ERG) recording. CFT, retinal res ponse density (RRD) and P-1 latency were measured. Results: There was no statistically significant difference between the two groups concerning CFT and P-1 latency in mf-ERG. The RRD in mf-ERG differed significantly between keratoconus patients and controls. Of note, BCVA was positively associated with RRD in keratoconus patients. Conclusion: In some cases of keratoconus, a macular dysfunction not visible ophthalmoscopically may coexist and the low visual acuity could be due not only to the corneal abnormality, but also to the photoreceptor dysfunction. As a result, the preoperative electrophysiological study of patients with keratoconus is crucial to avoid a needless corneal transplantation.

• 出版日期2013