3,5,6,7,8,3 ',4 '-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

作者：Okuyama Satoshi^*; Morita Mayu; Miyoshi Kazuhiro; Nishigawa Yuki; Kaji Miki; Sawamoto Atsushi; Terugo Tsukasa; Toyoda Nobuki; Makihata Nahomi; Amakura Yoshiaki; Yoshimura Mono; Nakajima Mitsunari; Furukawa Yoshiko

来源：Neurochemistry International, 2014, 70: 30-38.

DOI：10.1016/j.neuint.2014.03.008

• Heptamethoxyflavone
• Global cerebral ischemia
• Hippocampus
• BDNF
• Neuronal cell protection
• Anti-inflammation

The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.

• 出版日期2014-5