Increased error-related brain activity in generalized anxiety disorder

作者：Weinberg Anna; Olvet Doreen M; Hajcak Greg^*

来源：Biological Psychology, 2010, 85(3): 472-480.

DOI：10.1016/j.biopsycho.2010.09.011

• ERN
• Generalized anxiety disorder
• Anterior cingulate cortex
• Worry
• EEG
• ERP

The error-related negativity (ERN) is a negative deflection approximately 50 ms following an erroneous response, and is thought to reflect activity of the anterior cingulate cortex (ACC), a region of the medial prefrontal cortex implicated in the pathophysiology of a number of affective disorders, including generalized anxiety disorder (GAD). Pathological worry, the hallmark of GAD, has been linked to increased error-related brain activity, although no studies to date have examined the ERN among a clinical GAD sample. The present study measured electrocortical indices of error monitoring in a well-characterized, medication-free GAD sample. Brain activity was recorded in 17 GAD and 24 control subjects. The GAD group was characterized by a larger ERN and an increased difference between error and correct trials: a larger ERN was associated with increased self-reported anxiety and depression symptoms. Individuals with GAD have exaggerated early neural responses to errors, consistent with fMRI work implicating ACC abnormalities in GAD.

• 出版日期2010-12
• 单位河北医科大学