The relevance of hypothalamus-pituitary-adrenocortical axis-related hormones to the cochlear symptoms in Meniere's disease

作者：Aoki Mitsuhiro^*; Wakaoka Yoshinori; Hayashi Hisamitsu; Nishihori Takezumi; Kuze Bunya; Mizuta Keisuke; Ito Yatsuji

来源：International Journal of Audiology, 2011, 50(12): 897-904.

DOI：10.3109/14992027.2011.605807

• Cortisol
• dehydroepiandrosterone sulfate
• hearing levels
• Meniere's disease

Objective: To investigate the association of the HPA (hypothalamus-pituitary-adrenocortical) axis-related hormones with the progression of cochlear symptoms in patients with Meniere's disease. Design: Clinical assessments (Tinnitus Handicap Inventory: THI, visual analog scale to rate the degree of the tinnitus: VAS, hearing levels in pure-tone audiometry) were conducted upon entry into the study (baseline) and at 12 weeks follow-up (week 12). Blood sampling to measure HPA axis-related hormones took place between 9: 00 and 10: 00 a. m. at baseline and at 12 weeks follow-up. Study samples: This study consisted of 20 unilateral Meniere's disease patients and 21 patients with other diseases with unilateral sensorineural hearing loss and tinnitus. Results: A significant deterioration of the hearing level at high frequency range, especially at 2 kHz, was found during the 12 weeks follow-up in the Meniere's disease group (p < 0.05). The average hearing levels significantly correlated with the serum cortisol level at baseline and week 12 in the Meniere's disease group, especially regarding the high frequency levels (p < 0.01). Conclusions: Our results suggest that the cortisol levels influence the endolymphatic homeostasis resulting in a deterioration of hearing at high frequency with upstaging of Meniere's disease.

• 出版日期2011-12