Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes

作者：Jorsal Anders^*; Petersen Emilie Hein; Tarnow Lise; Hess Georg; Zdunek Dietmar; Frystyk Jan; Flyvbjerg Allan; Lajer Maria; Rossing Peter

来源：Journal of Diabetes and Its Complications, 2013, 27(6): 604-608.

DOI：10.1016/j.jdiacomp.2013.06.008

• Adiponectin
• Albuminuria
• Diabetes and kidney disease

Aim: Urinary adiponectin (u-adiponectin) excretion has been suggested to reflect early glomerular damage. Inspired by this, we studied the levels of u-adiponectin in type 1 diabetic patients with different levels of urinary albumin excretion (UAE). %26lt;br%26gt;Methods: U-adiponectin was analysed by ELISA in type 1 diabetic patients: Fifty-eight with normoalbuminuria (%26lt;30 mg albumin/24 h), 43 with persistent microalbuminuria (30-300 mg/24 h) and 44 with persistent macroalbuminuria (%26gt;300 mg/24 h). For comparison, a control group of 55 healthy individuals was included. %26lt;br%26gt;Results: U-adiponectin increased with increasing levels of UAE (p%26lt;0.01). U-adiponectin median (interquartile range): Normoalbuminuria 0.38 (0.14-1.31), microalbuminuria 1.12 (0.20-2.68), macroalbuminuria 9.20 (1.10-23.35) and controls 0.09 (0.06-0.24) mu g/g creatinine. Levels were unrelated to sex, age, cholesterol, diastolic BP and BMI. U-adiponectin was weakly associated with increasing systolic BP and HbA(1c) (r(2) %26lt; 0.1, p%26lt;0.05), but strongly related to increasing UAE (r(2) = 0.57, p %26lt; 0.001) and decreasing eGFR (r(2) = 0.26, p %26lt; 0.001). The relationship between UAE and u-adiponectin was significant in all groups and independent of eGFR, BMI, BP and HbA(1c). Furthermore, u-adiponectin was associated with markers of tubular damage (p%26lt;0.01). %26lt;br%26gt;Conclusion: U-adiponectin rises with increasing levels of UAE in patients with type 1 diabetes. This is in accordance with the hypothesis that loss of adiponectin may reflect glomerular and/or tubular damage.

• 出版日期2013-12