Association of Bilateral Brachial-Ankle Pulse Wave Velocity Difference with Peripheral Vascular Disease and Left Ventricular Mass Index

作者：Su Ho Ming; Lin Tsung Hsien; Hsu Po Chao; Lee Wen Hsien; Chu Chun Yuan; Chen Szu Chia^*; Lee Chee Siong; Voon Wen Chol; Lai Wen Ter; Sheu Sheng Hsiung

来源：PLos One, 2014, 9(2): e88331.

DOI：10.1371/journal.pone.0088331

Unequal arterial stiffness had been associated with cardiovascular risks. We investigated whether an association existed between unequal arterial stiffness indicated by bilateral brachial-ankle pulse wave velocity (baPWV) difference and anklebrachial index (ABI), baPWV, echocardiographic parameters and interarm and interankle systolic blood pressure (BP) differences. A total of 1111 patients referred for echocardiographic examination were included in this study. The BPs, ABI and baPWV were measured simultaneously by an ABI-form device. The Delta baPWV was defined as absolute value of difference between bilateral baPWV. We performed three multivariate analyses for determining the factors associated with a Delta baPWV %26gt;= 185 cm/s (90 percentile of Delta baPWV) (model 1: significant variables in univariate analysis and ABI %26lt;0.9 and baPWV; model 2: significant variables in univariate analysis and left ventricular mass index [LVMI]; model 3: significant variables in univariate analysis and interankle systolic BP difference %26gt;= 15 mmHg). The ABI %26lt;0.9 and high baPWV (both P%26lt;0.001) in model 1, high LVMI (P = 0.021) in model 2 and an interankle systolic BP difference %26gt;= 15 mmHg (P = 0.026) in model 3 were associated with a Delta baPWV %26gt;= 185 cm/s, but the interarm systolic BP difference %26gt;= 10 mmHg was not (P = NS). Our study demonstrated ABI, 0.9, high baPWV, high LVMI and an interankle systolic BP difference %26gt;= 15 mmHg were associated with unequal arterial stiffness.

• 出版日期2014-2-13