Using thermal and spectroscopic data to investigate the thermal behavior of epinephrine

作者：Bannach Gilbert; Cervini Priscila; Gomes Cavalheiro Eder Tadeu; Ionashiro Massao

来源：Thermochimica Acta, 2010, 499(1-2): 123-127.

DOI：10.1016/j.tca.2009.11.012

• Epinephrine
• Thermal decomposition
• Thermal stability
• TG-FTIR
• TG-DTA

Epinephrine is a neurotransmitter of the catecholamine class that acts in the mammalian central nervous system. The TG-DTA curves of epinephrine showed that the anhydrous compound starts decomposition at 165 degrees C, under the conditions used in this work. The reflectance FTIR spectra and X-ray powder diffraction patterns of epinephrine before and after heating up to 210 degrees C, as well as the TG-FTIR spectra of sample heated between 30 and 600 degrees C, were obtained and reveled that after heating, structural changes occurred in the sample. At temperatures higher than 205 degrees C the thermal decomposition took place with elimination of rnethylamine in agreement with the first mass loss observed in the TG curve in both air and N(2) atmospheres (TG = 17.0%, calcd. = 17.0%). The melting was observed at 205 degrees C (DTA) or 203 degrees C (DSC) but this process occurred overlapped with decomposition characteristic of an incongruent melting process.

• 出版日期2010-2-20