An efficient and recyclable bifunctional acid-base ionic liquid for synthesis of 1H-indazolo[1,2-b]phthalazinetriones

作者：Habibi Davood^*; Shamsian Atefeh

来源：Research on Chemical Intermediates, 2015, 41(9): 6245-6255.

DOI：10.1007/s11164-014-1736-0

• Bifunctional ionic liquid
• Green chemistry
• 1H-Indazolo[1,2-b]phthalazinetrione
• Solvent-free

A bifunctional ionic liquid, 1,4-dimethyl(4-sulfobutyl) piperazinium hydrogen sulfate ([DMSBP][HSO4], 1), containing both acid and basic sites was prepared. This ionic liquid was used as a homogeneous and reusable catalyst and efficiently promoted synthesis of 1H-indazolo[1,2-b]phthalazinetriones (5a-m) in a one-pot, four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide, dimedone, and aromatic aldehydes under solvent-free conditions at 80 degrees C. Advantages of the method include short reaction time, high yields, and simple purification.

• 出版日期2015-9