Derivatives of 4-amino-4H-1,2,4-triazole-3-thiols linked to pyrrole cycle and some products of their S-alkylation

作者：Bijev A T^*; Prodanova P

来源：Khimiya Geterotsiklicheskikh Soedinenii, 2007, (3): 383-391.

• pyrroles
• 4H-1,2,4-triazole
• alkylation
• cyclization

The study offers an access to 21 new heterocyclic compounds representing pyrrole derivatives of 4-amino-4H-1,2,4-triazole-3-thiols or 1,3,4-oxadiazole-2-thiols. The principal synthetic approach is based on the cyclization of substituted potassium 2-(pyrrolecarbonyl)hydrazine-1-carbodithionate with hydrazine hydrate to 5-(substituted pyrrolyl)-4-amino-4H-1,2,4-triazole-3-th- ols, followed by S-alkylation with methyl iodide or benzyl chloride. Among the resulted thirteen S-alkyl derivatives, five 1,3,4-oxadiazole derivatives have been isolated as secondary products and their formation is explained as a result of S-alkylation of intermediate 1,3,4-oxadiazole-2-thiols, generated in the alkaline medium.

• 出版日期2007-3
• 单位北京化工大学