Developmental programming: The concept, large animal models, and the key role of uteroplacental vascular development

作者：Reynolds L P^*; Borowicz P P; Caton J S; Vonnahme K A; Luther J S; Hammer C J; Carlin K R Maddock; Grazul Bilska A T; Redmer D A

来源：Journal of Animal Science, 2010, 88: E61-E72.

DOI：10.2527/jas.2009-2359

• developmental programming
• large animal model
• placental dysfunction
• stress

Developmental programming refers to the programming of various bodily systems and processes by a stressor of the maternal system during pregnancy or during the neonatal period. Such stressors include nutritional stress, multiple pregnancy (i.e., increased numbers of fetuses in the gravid uterus), environmental stress (e.g., high environmental temperature, high altitude, prenatal steroid exposure), gynecological immaturity, and maternal or fetal genotype. Programming refers to impaired function of numerous bodily systems or processes, leading to poor growth, altered body composition, metabolic dysfunction, and poor productivity (e.g., poor growth, reproductive dysfunction) of the offspring throughout their lifespan and even across generations. A key component of developmental programming seems to be placental dysfunction, leading to altered fetal growth and development. We discuss various large animal models of developmental programming and how they have and will continue to contribute to our understanding of the mechanisms underlying altered placental function and developmental programming, and, further, how large animal models also will be critical to the identification and application of therapeutic strategies that will alleviate the negative consequences of developmental programming to improve offspring performance in livestock production and human medicine.

• 出版日期2010-4