Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins

作者：Kato Eisuke^*; Kushibiki Natsuka; Inagaki Yosuke; Kurokawa Mihoko; Kawabata Jun

来源：Bioscience Biotechnology and Biochemistry, 2017, 81(9): 1699-1705.

DOI：10.1080/09168451.2017.1353403

• pancreatic -amylase
• type 2 diabetes
• procyanidin
• Astilbe thunbergii

Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic -amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the -amylase inhibitory component with IC50=1.7g/mL against porcine pancreatic -amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable -amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention.

• 出版日期2017