Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate

作者：Kanoh Naoki^*; Mano Kosuke; Saigusa Daisuke; Usui Takeo; Iwabuchi Yoshiharu

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(23): 5770-5772.

DOI：10.1016/j.bmcl.2016.10.046

• Phosphatidylinositol 3,5-bisphosphates
• Acetoxymethyl ester
• Dioctanoyl analog
• Chemical synthesis

Extracellular administration of water-soluble and membrane-permeant analogs of phosphatidylinositol phosphates (PIPs) is a useful strategy for understanding the cellular roles of PIPs as well as the mode of action of drugs whose biological activity is associated with PIPs. We herein established the synthetic route to the dioctanoyl analogue of phosphatidylinositol 3,5-bisphosphate (di-C-8-PI(3,5)P-2) and its penta (acetoxymethyl) ester (di-C-8-PI(3,5) P-2/5AM).

• 出版日期2016-12-1