Early Detection of Left Ventricular Systolic Dysfunction Using Two-Dimensional Speckle Tracking Strain Evaluation in Healthy Subjects after Acute Alcohol Intoxication

作者：Reant Patricia^*; Chasseriaud Warren; Pillois Xavier; Dijos Marina; Arsac Florence; Roudaut Raymond; Lafitte Stephane

来源：Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 2012, 29(8): 927-932.

DOI：10.1111/j.1540-8175.2012.01717.x

• binge drinking
• speckle tracking strain echocardiography
• alcohol intoxication

Objectives: We evaluated the ability of two-dimensional speckle tracking strain echocardiography to detect left ventricular (LV) systolic dysfunction as compared with LV ejection fraction (EF) in healthy subjects following acute alcohol intoxication. Methods and Results: In total, 25 healthy subjects were investigated using echocardiography 46 hours after the onset of alcohol intoxication at a regional festive gathering, and then compared to 23 healthy control subjects without alcohol consumption. Heart rate, blood pressure, blood alcohol level, LV volumes, EF, shortening fraction, E/A ratio, as well as global longitudinal strain (LS) were recorded. Mean blood alcohol level was 1.3 +/- 0.3 g.L-1. Mean systolic blood pressure and heart rate were slightly increased in the alcohol group compared to controls (147.5 +/- 21.8 mmHg vs 127.0 +/- 9.9 mmHg, P = 0.003, and 79.7 +/- 10.7 bpm vs 70.6 +/- 7.6 bpm, P < 0.001, respectively). While there was no significant difference in terms of LVEF (62.9 +/- 4.4% vs 64.8 +/- 5.9%, P = 0.18) or shortening fraction (34.7 +/- 5.9% vs 36.0 +/- 4.3%, P = 0.54), global LS was significantly impaired (17.8 +/- 2.0% vs -21.2 +/- 1.8%, P < 0.001). In addition, subjects who consumed alcohol had increased LV end-diastolic (108.3 +/- 20.1 mL vs 95.5 +/- 14.6 mL, P = 0.037) and end-systolic volumes (41.6 +/- 11.4 mL vs 33.7 +/- 6.9 mL, P = 0.024), along with depressed aortic time-velocity integral (19.9 +/- 3.2 mL vs 21.9 +/- 2.5 mL, P = 0.034). According to multivariate linear regression analyses, blood alcohol level was the only factor significantly associated with global LS (beta=-3.6 +/- 1.0, P = 0.005). Conclusion: Alcohol intoxication around festive days induces acute LV contraction abnormalities, which may be detected using global LS by speckle tracking at an earlier stage and more accurately than LVEF decreases.

• 出版日期2012-9
• 单位河南工业大学