Assessment of anticholinesterase and antioxidant properties of selected sage (Salvia) species with their total phenol and flavonoid contents

作者：Orhan Ilkay Erdogan^*; Senol Fatma Sezer; Ercetin Tugba; Kahraman Ahmet; Celep Ferhat; Akaydin Galip; Sener Bilge; Dogan Musa

来源：Industrial Crops and Products, 2013, 41: 21-30.

DOI：10.1016/j.indcrop.2012.04.002

• Salvia
• Sage
• Cholinesterase inhibition
• Alzheimer%26apos
• s disease
• Antioxidant activity

In this study, cholinesterase inhibitory potential relevant to Alzheimer%26apos;s disease and antioxidant activities of the dichloromethane, ethyl acetate, and ethanol extracts from the aerial parts and/or roots of fourteen Salvia (sage) species (S. argentea, S. bracteata, S. caespitosa, S. cryptantha, S. glutinosa, S. indica, S. microstegia, S. multicaulis, S. pinnata, S. quezelii, S. syriaca, S. tobeyi, S. verticillata subsp. amasiaca, and S. viscosa) were investigated. Cholinesterase inhibition was determined by Ellman method at 25, 50, and 100 mu g ml(-1). Their antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, metal-chelation capacity, and ferric-reducing antioxidant power (FRAP) assays. Total phenol and flavonoid contents of the extracts were also determined. The dichloromethane and ethanol extracts of the aerial parts of S. cryptantha were the most active ones against AChE (56.22 +/- 1.07%) and BChE (33.80 +/- 4.18%), respectively. The ethanol extracts exhibited better scavenging activity and FRAP. Anticholinesterase activity of 9 Salvia species (S. argentea, S. bracteata, S. caespitosa, S. indica, S. pinnata, S. quezelii, S. syriaca, S. tobeyi, and S. viscosa) is reported for the first time in the current study.

• 出版日期2013-1