DISTINCT NEURAL PROCESSES SUPPORT POST-SUCCESS AND POST-ERROR SLOWING IN THE STOP SIGNAL TASK

作者：Zhang, Yihe; Ide, Jaime S.; Zhang, Sheng; Hu, Sien; Valchev, Nikola S.; Tang, Xiaoying^*; Li, Chiang-Shan R.^*

来源：Neuroscience, 2017, 357: 273-284.

DOI：10.1016/j.neuroscience.2017.06.011

• post-signal slowing
• go/no-go
• cognitive control
• error processing
• fMRI

Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the right-hemispheric ventrolateral prefrontal cortex, in the area of inferior frontal gyrus, pars opercularis (IFGpo) and anterior insula (AI), during post-error slowing (PES). However, in similar analyses we were not able to identify regional activities during post success slowing (PSS). Here, we revisited this issue in a larger sample of participants (n = 100) each performing the SST for 40 min during fMRI. We replicated IFGpo/AI activation to PES (p <= 0.05, FWE corrected). Further, PSS engages decreased activation in a number of cortical regions including the left inferior frontal cortex (IFC; p <= 0.05, FWE corrected). We employed Granger causality mapping to identify areas that provide inputs each to the right IFGpo/AI and left IFC, and computed single-trial amplitude (STA) of stop trials of these input regions as well as the STA of post-stop trials of the right IFGpo/AI and left IFC. The STAs of the right inferior precentral sulcus and supplementary motor area (SMA) and right IFGpo/AI were positively correlated and the STAs of the left SMA and left IFC were positively correlated (slope > 0, p's <= 0.01, one-sample t test), linking regional responses during stop success and error trials to those during PSS and PES. These findings suggest distinct neural mechanisms to support PSS and PES.

• 出版日期2017-8-15
• 单位北京回龙观医院; 上海市精神卫生中心; 北京理工大学