Development of a nomogram incorporating serum C-reactive protein level to predict overall survival of patients with advanced urothelial carcinoma and its evaluation by decision curve analysis

作者：Ishioka J; Saito K^*; Sakura M; Yokoyama M; Matsuoka Y; Numao N; Koga F; Masuda H; Fujii Y; Kawakami S; Kihara K

来源：British Journal of Cancer, 2012, 107(7): 1031-1036.

DOI：10.1038/bjc.2012.254

• C-reactive protein
• advanced urothelial carcinoma
• biomarker
• survival prediction
• nomogram
• decision curve analysis

BACKGROUND: The purpose of this study is to investigate the prognostic impact of C-reactive protein (CRP) on patients with advanced urothelial carcinoma and to develop a novel nomogram predicting survival. %26lt;br%26gt;METHODS: A total of 223 consecutive patients were treated at Tokyo Medical and Dental Hospital. A nomogram incorporating V was developed based on the result of a Cox proportional hazards model. Its efficacy and clinical usefulness was evaluated by concordance index (c-index) and decision curve analysis. %26lt;br%26gt;RESULTS: Of the 223 patients, 184 (83%) died of cancer. Median follow-up periods of patients who died and those who remained alive were 5 and 11 months, respectively. We developed a novel nomogram incorporating Eastern Cooperative Oncology Group Performance Status, presence of visceral metastasis, haemoglobin and age. The c-index of the nomogram predicting survival probability 6 and 12 months after diagnosis was 0.788 and 0.765, respectively. Decision curve analyses revealed that the novel nomogram incorporating CRP had a superior net benefit than that without CRP for most of the examined probabilities. %26lt;br%26gt;CONCLUSION: We demonstrated the prognostic impact of CRP that improved the predictive accuracy of a nomogram for survival probability in patients with advanced urothelial carcinoma. British Journal of Cancer (2012) 107, 1031-1036. doi:10.1038/bjc.2012.254 www.bjcancer.

• 出版日期2012-9-25