An Optimization-Based Design Framework for Steering Steady States and Improving Robustness of Glycolysis-Glycogenolysis Pathway

作者：Panja Surajit; Patra Sourav; Mukherjee Anirban^*; Basu Madhumita; Sengupta Sanghamitra; Dutta Pranab K

来源：IEEE Transactions on Biomedical Engineering, 2013, 60(2): 554-561.

DOI：10.1109/TBME.2012.2230259

• Glycogenolysis
• glycolysis
• linear matrix inequality (LMI)
• robustness
• S-system

A robust synthesis technique is devised for synergism and saturation systems, commonly known as S-systems, for controlling the steady states of the glycolysis-glycogenolysis pathway. The development of the robust biochemical network is essential owing to the fragile response to the perturbation of intrinsic and extrinsic parameters of the nominal S-system. The synthesis problem is formulated in a computationally attractive convex optimization framework. The linear matrix inequalities are framed to aim at the minimization of steady-state error, improvement of robustness, and utilization of minimum control input to the biochemical network.

• 出版日期2013-2