Autophagy as an immune effector against tuberculosis

作者：Bradfute Steven B; Castillo Eliseo F; Arko Mensah John; Chauhan Santosh; Jiang Shanya; Mandell Michael; Deretic Vojo^*

来源：Current Opinion in Microbiology, 2013, 16(3): 355-365.

DOI：10.1016/j.mib.2013.05.003

The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue-sparing functions of autophagy. Complementing these observations, genome wide association studies indicate a considerable overlap between autophagy, human susceptibility to mycobacterial infections and predisposition loci for inflammatory bowel disease. Finally, recent studies show that autophagy is an important regulator and effector of IL-1 responses, and that autophagy intersects with type I interferon pathology-modulating responses.

• 出版日期2013-6