An efficient method for the synthesis of 1,5-benzodiazepine derivatives under microwave irradiation without solvent

作者：Pozarentzi M; Stephanidou Stephanatou J^*; Tsoleridis CA

来源：Tetrahedron Letters, 2002, 43(9): 1755-1758.

DOI：10.1016/S0040-4039(02)00115-6

• benzodiazepines
• o-phenylenediamines
• microwave irradiation
• green chemistry

2, 3-Dihydro-1H-1.5-benzodiazepines have been synthesized in solvent-free conditions from o-phenylenediamines and ketones in the presence of a catalytic amount of acetic acid, under microwave irradiation. This method is a very easy, rapid and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives.

• 出版日期2002-2-25