A Newborn Screening System Based on Service-Oriented Architecture Embedded Support Vector Machine

作者：Hsu Kai Ping; Hsieh Sung Huai; Hsieh Sheau Ling; Cheng Po Hsun; Weng Yung Ching; Wu Jang Hung; Lai Feipei

来源：Journal of Medical Systems, 2010, 34(5): 899-907.

DOI：10.1007/s10916-009-9305-6

• Web services
• Newborn screening
• Service-Oriented Architecture
• Tandem mass spectrometry
• Support Vector Machine

The clinical symptoms of metabolic disorders are rarely apparent during the neonatal period, and if they are not treated earlier, irreversible damages, such as mental retardation or even death, may occur. Therefore, the practice of newborn screening is essential to prevent permanent disabilities in newborns. In the paper, we design, implement a newborn screening system using Support Vector Machine (SVM) classifications. By evaluating metabolic substances data collected from tandem mass spectrometry (MS/MS), we can interpret and determine whether a newborn has a metabolic disorder. In addition, National Taiwan University Hospital Information System (NTUHIS) has been developed and implemented to integrate heterogeneous platforms, protocols, databases as well as applications. To expedite adapting the diversities, we deploy Service-Oriented Architecture (SOA) concepts to the newborn screening system based on web services. The system can be embedded seamlessly into NTUHIS.

• 出版日期2010-10