Maternal Serum Placental Growth Factor Isoforms 1 and 2 at 11-13, 20-24 and 30-34 Weeks' Gestation in Late-Onset Pre-Eclampsia and Small for Gestational Age Neonates

作者：Nucci Marta; Poon Leona C; Demirdjian Gaiane; Darbouret Bruno; Nicolaides Kypros H^*

来源：Fetal Diagnosis and Therapy, 2014, 35(4): 249-257.

DOI：10.1159/000358595

• Pyramid
• Placental growth factor
• Isoforms
• Small for gestational age
• Pre-eclampsia

Objective: To compare the maternal serum concentrations of placental growth factor (PIGF)-1 and PIGF-2 in the first, second and third trimesters in normal pregnancies and in those complicated by pre-eclampsia (PE) or the delivery of small for gestational age (SGA) neonates after 37 weeks. Methods: Serum PIGF-1 and PIGF-2 were measured at 11-13, 20-24 and 30-34 weeks' gestation in 50 cases of PE, 99 cases of SGA and 298 controls. The values of PIGF-1 and PIGF-2 at 11-13 weeks were expressed as multiples of the median (MoM) after adjustment for maternal characteristics. The distributions of PIGF-1 and PIGF-2 in cases and controls at 20-24 and 30-34 weeks were converted to MoM of the values at 11-13 weeks and compared. Results: Serum PIGF-1 and PIGF-2 levels were highly correlated and both increased with gestational age. At 30-34 weeks, the median MoM values for PIGF-1 and PIGF-2 in the late PE (4.2 and 4.3) and late SGA (7.2 and 6.0) groups were significantly lower than in the controls (12.8 and 9.9). Combining the two isoforms did not improve the prediction of late PE and late SGA provided by PIGF-1 alone. Conclusions:The performances of serum PIGF-1 and PIGF-2 in the prediction of late PE and late SGA are similar.

• 出版日期2014