A Single Fasting Plasma 5-HIAA Value Correlates With 24-Hour Urinary 5-HIAA Values and Other Biomarkers in Midgut Neuroendocrine Tumors (NETs)

作者：Tellez Maria R; Mamikunian Gregg; O' Dorisio Thomas M; Vinik Aaron I; Woltering Eugene A^*

来源：Pancreas, 2013, 42(3): 405-410.

DOI：10.1097/MPA.0b013e318271c0d5

• 5-hydroxyindoleacetic acid
• 5-HIAA
• neuroendocrine tumors
• midgut
• serotonin
• carcinoid syndrome

Objectives: 5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine collection. %26lt;br%26gt;Methods: We developed a gas chromatography mass spectroscopy-based plasma 5-HIAA assay. We compared 24-hour urine 5-HIAA values against plasma 5-HIAA values in 115 mixed-variety patients with NETs and in a subset of 72 patients with only small bowel NETs. We also compared the information gained from urinary and plasma 5-HIAA values with other biomarkers of midgut NET activity to determine the plasma assay%26apos;s clinical implications. %26lt;br%26gt;Results: In a group of 115 patients with all types of NETS, in a subset of patients with midgut NET and in a subgroup of midgut NETS with liver metastasis, the correlation between the urine and fasting plasma 5-HIAA values were statistically significant (P %26lt;= 0.0001). Comparison of the proportion of normal or abnormal urinary and plasma 5-HIAA values to the proportion of chromogranin, serotonin, neurokinin, or pancreastatin values that were in the normal or abnormal range yielded essentially identical information. %26lt;br%26gt;Conclusions: Plasma fasting 5-HIAA values are proportional to urinary 5-HIAA values and yielded identical clinical correlation with other biomarkers.

• 出版日期2013-4