An efficient route to pyridine and 2,2 '-bipyridine macrocycles incorporating a triethylenetetraminetetraacetic acid core as ligand for lanthanide ions

作者：Bechara Ghassan; Leygue Nadine; Galaup Chantal; Mestre Beatrice; Picard Claude^*

来源：Tetrahedron Letters, 2009, 50(47): 6522-6525.

DOI：10.1016/j.tetlet.2009.09.030

• Polyazapolycarboxylic acid
• Functionalized polyamine
• Macrocyclic ligand
• Pyridine
• Terbium
• Luminescence

Two novel macrocyclic chelators L(1) and L(2) incorporating an intracyclic pyridine or 2,2'-bipyridine unit and a triethylenetetraminetetraacetic acid core (TITA) were synthesized with the aim of forming lanthanide complexes suitable as efficient long-lived luminophores. For this goal, an efficient methodology for the preparation of TITA derivatives using prealkylated precursors is described Starting from commercially available compounds, the target ligands were obtained in seven (L(1)) and nine (L(2)) steps in 40% and 20% overall yields. respectively. Stable Tb(III) complexes were prepared and displayed interesting luminescence properties.

• 出版日期2009-11-25