Association between respiratory symptom score and 30-year cause-specific mortality and lung cancer incidence

作者：Frostad A^*

来源：Clinical Respiratory Journal, 2008, 2: 53-58.

DOI：10.1111/j.1752-699X.2008.00084.x

• cohort study
• ischaemic heart disease
• lung cancer incidence
• mortality
• obstructive
• lung disease
• pneumonia
• respiratory symptom score
• stroke

Introduction: Respiratory symptoms are among the main reasons why patients make contact with healthcare professionals and they are associated with several diseases.
Objective: The aim of this study was to investigate the relationship between respiratory symptoms reported at one time and 30 years cause-specific mortality and incidence of lung cancer in an urban Norwegian population.
Materials and Methods: A total of 19 998 men and women, aged 15-70 years, were in 1972 selected from the general population of Oslo. They received a postal respiratory questionnaire (response rate 89%). All were followed for 30 years for end-point mortality and for lung cancer. The association between respiratory symptoms, given as a symptom load, and end point of interest were investigated separately for men and women by mUltivariable analyses, with adjustment for age, occupational exposure to air pollution and smoking habits.
Results: A total of 6710 individuals died during follow-up. Obstructive lung diseases (OLDs) and pneumonia accounted for 250 and 293 of the total deaths, respectively. Ischaemic heart disease (IHD) accounted for 1572; stroke accounted for 653 of all deaths. Lung cancer developed in 352 persons during follow-up. The adjusted hazard ratio for mortality from OLD and pneumonia, IHD and stroke increased in a dose-response manner with symptom score, more strongly for OLD and IHD than for pneumonia and stroke.
Conclusions: Respiratory symptoms were positively associated with mortality from OLD, pneumonia, IHD and stroke, and incidence of lung cancer. This association was significant for mortality from OLD and IHD.

• 出版日期2008-10
• 单位河北医科大学