An eco-friendly Co(OAc)(2)-catalyzed aerobic oxidation of 4-benzylphenols into 4-hydroxybenzophenones

作者：Huang, Jian-Gang; Guo, Ying; Jiang, Jian-An; Liu, Hong-Wei; Ji, Ya-Fei^*

来源：Research on Chemical Intermediates, 2015, 41(10): 7115-7124.

DOI：10.1007/s11164-014-1801-8

• 4-Benzylphenols
• 4-Hydroxybenzophenones
• Aerobic oxidation
• Co(OAc)(2)center dot 4H(2)O
• Ethylene glycol

An undecorated Co(OAc)(2)-catalyzed aerobic oxidation system has been reported that enables direct transformation of 4-benzylphenols into the corresponding 4-hydroxybenzophenones. The procedure is especially suitable for electron-withdrawing group-containing substrates, which are commonly inefficient to conduct this category of oxidation. Based on well-defined p-benzoquinone methides and the confirmed ethereal intermediate, a plausible mechanism was depicted.

• 出版日期2015-10
• 单位华东理工大学